Job Description Vertex is seeking an on-site Principal Research Associate, Analytical Chemistry to support medicinal chemistry programs through small molecule purification, analytical characterization, property assays and workflow optimization. This role will focus on HPLC and SFC purification, with a strong emphasis on SFC expertise, to help deliver high-quality compounds and data that enable rapid discovery efforts. Key
Duties
and
Responsibilities
Purify small molecules using HPLC and SFC in support of medicinal chemistry programs. Develop and optimize SFC purification methods, including chiral and achiral separations. Perform analytical testing to confirm purity, identity, and quality of compounds. Run small molecule property assays such as solubility, lipophilicity, and stability assessments. Partner closely with medicinal chemists to support project timelines and compound delivery needs. Troubleshoot purification and assay issues and help improve lab workflows. Maintain accurate records and clearly communicate results to project teams. Support routine operation and maintenance of chromatography instruments. Knowledge and Skills: Small molecule purification and characterization Laboratory data systems and electronic lab notebooks Familiarity with discovery informatics or compound tracking systems
Experience
with software development, scripting, or coding Ability to work effectively in cross-functional teams Strong written and verbal communication skills Demonstrated ability to work independently, manage priorities, and drive technical work with limited oversight
Education
and
Experience
Requires a Master's and 2+ years, or a Bachelor's and 5+ years of experience, or the equivalent combination of education and experience
Experience
supporting small molecule discovery or medicinal chemistry programs Strong hands-on experience with HPLC and/or SFC purification Strong organizational, communication, and collaboration skills #LI-KM1 #LI-Onsite
Pay Range
$85,700 - $128,500 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.