Senior Scientist, Vaccine Drug Product Development Introduction to the Role Join our Vaccines Drug Product Development team to shape the next generation of preventative therapies. We are seeking a highly motivated Senior Scientist with experience in vaccine formulation development, adjuvant formulations, and co-formulated drug products. You will design and develop formulations and drug product processes spanning phase 1 through pivotal clinical development, with a focus on multi-antigen/adjuvant combinations and other vaccine modalities. You will drive development strategies, influence CMC decisions, manage external partners, and connect near-term deliverables to long-term patient impacts. Key
Responsibilities
You will work in a laboratory environment focused on vaccine drug product development, supporting programs from early formulation screening through clinical manufacturing readiness. Additionally, you will: Vaccine Formulation Development: Design and execute formulation studies for vaccine drug products, including co-formulated multi-antigen/adjuvant combinations and other vaccine modalities. Evaluate antigen–adjuvant interactions, excipient compatibility, and stability to inform pipeline advancement decisions. In Vitro Characterization: Perform experiments to evaluate formulation attributes such as antigen integrity, adsorption/desorption profiles, particle size, encapsulation efficiency, and colloidal stability. Generate data packages that support formulation down-selection and process development decisions. Drug Product Process Design and Scale-Up: Design fit-for-purpose drug product processes (e.g., mixing, encapsulation, sterile filtration, lyophilization). Conduct scale-up and robustness studies to build process–product understanding across clinical phases. Contribute to technology transfer activities to manufacturing sites or CMOs/CDMOs. Documentation and Regulatory Authoring: Author technical reports, protocols, and development summaries. Draft and contribute to CMC sections for INDs, and BLAs (i.e., process descriptions, formulation justifications, clinical compatibility). Maintain documentation in compliance with internal practices. Cross-Functional Representation: Represent Drug Product on CMC sub-teams; collaborate with other functions to align formulation and process plans with program timelines. Scientific Contribution and Lab Operations: Present findings at internal forums; contribute to external publications or conferences where appropriate. Stay current with emerging scientific literature and technology. Support coordination and maintenance of laboratory equipment.
Education
&
Experience
Requirements
Education
BS, MS, or PhD in Biochemistry, Chemistry, Chemical/Biochemical Engineering, Immunology, Pharmaceutics or related fields of study.
Experience
BS: 7+ years; MS: 3+ years; PhD: 0+ years of experience in biopharmaceutical or vaccine development. Required Skills &
Experience
Formulation Development: Strong understanding of vaccine formulation principles, including adsorption kinetics, antigen–adjuvant interactions, buffer/excipient selection, and stability assessment (chemical, physical, colloidal). Ability to independently design and execute formulation studies with clear decision criteria. In Vitro Characterization: Familiarity with biophysical characterization techniques such as DLS, HPLC/UPLC, LC-MS, UV/Fluorescence, ELISA/Binding assays, DSC/DMA, zeta potential, encapsulation efficiency, particle size and PDI, adsorption/desorption profiling, residual solvent/detergent analysis, Karl Fischer, osmolality, sterility/endotoxin, and appearance/particulate assessments. Data Interpretation & Decision-Making: Ability to design experiments with clear decision criteria, critically interpret results, and connect experimental outcomes to inform next steps. Process Engineering: Familiarity with unit operations relevant to vaccines (e.g., homogenization/emulsification, sterile filtration concepts, or LNP formation via microfluidics). Exposure to process scale-up considerations is a plus. Scientific Communication: Ability to clearly document experimental work, summarize findings in written reports, and present data to multidisciplinary teams. Collaboration: Strong communication and interpersonal skills, with the ability to work effectively across multidisciplinary scientific teams. Desirable Skills &
Experience
Process Engineering:
Experience
with unit operations relevant to vaccines (e.g., homogenization/emulsification, sterile filtration, LNP formation via microfluidics, lyophilization). Hands-on experience with process scale-up or tech transfer is preferred. CMC and GMP Familiarity:
Experience
working within or interfacing with GMP manufacturing environments, reviewing batch records, or coordinating with CMOs/CDMOs. Regulatory Authoring: Direct experience authoring or reviewing CMC sections for regulatory filings (IND, BLA). External Scientific Engagement: Track record of conference presentations, publications, or patent contributions. Ways of Working and Behaviors Proactive and Motivated: Anticipates risks and opportunities; drives timely, high-quality execution with minimal supervision. Collaborative and Engaged: Builds strong relationships across disciplines; communicates clearly; fosters transparency and shared accountability. Patient Impact Focus: Passionate about translating technical work into better patient outcomes; prioritizes quality, and safety. Scientific Rigor and Integrity: Upholds data integrity, methodical experimentation, and clear documentation; embraces feedback to improve outcomes. Working Model This is a lab-based position with an on-site requirement. However, there is flexibility for remote work based on individual needs and team priorities. Location and Travel Primary Site: Gaithersburg, MD (Biopharmaceuticals R&D) Travel: Up to10% travel, primarily to CMOs/CDMOs, and internal manufacturing sites Why AstraZeneca? At AstraZeneca’s Biopharmaceuticals R&D, you will join a community of scientists committed to advancing vaccine science with courage and clarity. Here, every challenge is an opportunity to learn and improve. You will have the opportunity to shape CMC strategies and deliver tangible impact for patients worldwide. The annual base pay for this position ranges from $112,304 to $168,456. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
Benefits
offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans Date Posted 14-Aug-2026 Closing Date 27-Aug-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.