Career Category Information Systems Job Description We are seeking a Sr Machine Learning Engineer—Amgen’s most senior individual-contributor authority on building and scaling end-to-end machine-learning and generative-AI platforms. Sitting at the intersection of engineering excellence and data-science enablement, you will design the core services, infrastructure and governance controls that allow hundreds of practitioners to prototype, deploy and monitor models—classical ML, deep learning and LLMs—securely and cost-effectively. Acting as a “player-coach,” you will establish platform strategy, define technical standards, and partner with DevOps, Security, Compliance and Product teams to deliver a frictionless, enterprise-grade AI developer experience. Roles & Responsibilities: Engineer end-to-end ML pipelines—data ingestion, feature engineering, training, hyper-parameter optimization, evaluation, registration and automated promotion—using Kubeflow, SageMaker Pipelines, Open AI SDK or equivalent MLOps stacks. Harden research code into production-grade micro-services, packaging models in Docker/Kubernetes and exposing secure REST, gRPC or event-driven APIs for consumption by downstream applications. Build and maintain full-stack AI applications by integrating model services with lightweight UI components, workflow engines or business-logic layers so insights reach users with sub-second latency. Optimize performance and cost at scale—selecting appropriate algorithms (gradient-boosted trees, transformers, time-series models, classical statistics), applying quantization/pruning, and tuning GPU/CPU auto-scaling policies to meet strict SLA targets. Instrument comprehensive observability—real-time metrics, distributed tracing, drift & bias detection and user-behavior analytics—enabling rapid diagnosis and continuous improvement of live models and applications. Embed security and responsible-AI controls (data encryption, access policies, lineage tracking, explainability and bias monitoring) in partnership with Security, Privacy and Compliance teams. Contribute reusable platform components—feature stores, model registries, experiment-tracking libraries—and evangelize best practices that raise engineering velocity across squads. Perform exploratory data analysis and feature ideation on complex, high-dimensional datasets to inform algorithm selection and ensure model robustness. Partner with data scientists to prototype and benchmark new algorithms, offering guidance on scalability trade-offs and production-readiness while co-owning model-performance KPIs. Must-Have Skills: 3-5 years in AI/ML and enterprise software. Comprehensive command of machine-learning algorithms—regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, deep-learning architectures (CNNs, RNNs, transformers) and modern LLM/RAG techniques—with the judgment to choose, tune and operationalise the right method for a given business problem. Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale. Expert knowledge of GenAI tooling: vector databases, RAG pipelines, prompt-engineering DSLs and agent frameworks (e.g., LangChain, Semantic Kernel). Proficiency in Python and Java; containerisation (Docker/K8s); cloud (AWS, Azure or GCP) and modern DevOps/MLOps (GitHub Actions, Bedrock/SageMaker Pipelines). Strong business-case skills—able to model TCO vs. NPV and present trade-offs to executives. Exceptional stakeholder management; can translate complex technical concepts into concise, outcome-oriented narratives. . Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen