The ideal candidate will have strong background in pharmacokinetics and translational modeling. You will participate in implementing innovative and quantitative approaches to advance clinical drug development. Developing, qualifying, and applying mechanistic PBPK models using in vitro, preclinical, clinical, and literature data to support clinical development decisions across therapy areas. In addition, you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology (CPQP) as per your experience, interests, and expertise dictate. Typical Accountabilities Utilize physiologically-based pharmacokinetic (PBPK) and translational modeling tools to enable clinical PK projections for drug-drug interactions (DDIs), pediatric and other specific populations, and other clinical development questions Collaborate with Drug Metabolism and Pharmacokinetic (DMPK) Scientists and Clinical Pharmacology scientists to generate these mechanistic models Develop fit-for-purpose, qualified PBPK models suitable for internal decision-making and regulatory use, including support for submission documentation and health authority interactions. Communicate clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions Keep up to date with emerging literature, modeling science, and regulatory expectations Education, Qualifications, Skills and

Experience

Essential PhD degree preferred or equivalent (M.Sc./Pharm.D.)

Experience

using PBPK platforms such as Simcyp, GastroPlus, or PK-Sim, together with scripting in R and/or Python for data analysis, visualization, and workflow automation. Familiarity with AI-enabled scientific workflows, such as literature mining, coding assistance, or document summarization in compliant research environments Demonstrated broad PBPK expertise and experience exemplified by 1-4 Years of drug development experience, with emphasis on PBPK modelling Good knowledge in pharmacokinetics, drug-drug interactions, regulatory guidance in clinical pharmacology, modelling and simulation sciences Demonstrated ability to identify, develop and execute PBPK activities at a project level Good oral and written communication skills Good knowledge of global regulatory, compliance, processes, standards and issues specific to PBPK with relevant experience required

Experience

authoring or contributing to PBPK technical reports and regulatory documentation, including submission-ready analyses and responses to health authority queries.Fluency in spoken and written English language Desirable A reputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology

Experience

in early and late-stage drug development Date Posted 11-ago-2026 Closing Date 30-ago-2026 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.