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Job Title: Researcher 3-Medical Oncology Department: Medicine | IM Medical Oncology Researcher responsible for performing experiments and managing projects in a clinical/translational lung cancer research lab. Planned projects are translationally important from clinical perspective and will employ cutting edge laboratory and analytical techniques. This role will focus on tumor signaling and interactions with the immune microenvironment in lung tumors that have loss of the LKB1 tumor suppressor, with goals of gaining mechanistic insight into the important clinical question of why these tumors are resistant to immunotherapy treatments, and identification and testing of candidate pathways that could be targeted to enhance immune sensitivity. Using in vitro (tumor cell lines, and a T-cell co-culture system) and in vivo model systems (murine cell lines from an LKB1 deficient GEMM that can be used for immunocompetent allograft experiments, as well as the GEMM model itself), to test hypotheses on pathways responsible for immune resistance. Conduct cutting edge high throughput experiments with functional genomics screens (e.g. CRISPRi based screens), proteomics and phosphoproteomics, single cell RNAseq, to help dissect out the mechanisms that may be responsible for these effects, which can both strengthen conclusions from hypothesis based mechanistic studies, and also can be used to gain novel insights and identify new hypotheses. Results from preclinical work will be integrated with analyses from existing multi-omic data, and also access to clinical trial specimens and/or OSU clinical cohorts to test ideas in specimens from lung cancer patients. MINIMUM REQUIRED QUALIFICATIONS Master's Degree in Biological Sciences or relevant field, or equivalent experience required; 5 years of relevant experience required with Bachelor's Degree, or 3 years of relevant experience required with Master's Degree. A background in cancer biology and/or immunology is a plus. Function: Research and Scholarship Sub Function: Research Career Band: Individual Contributor – Specialized Career Level: S3 Additional Information: The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nation’s largest and most comprehensive public universities and a top employer in Ohio. As one of only 57 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies – providing tomorrow’s standard of care today. A Cancer-Free World Begins Here. The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities. is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities. Location: Biomedical Research Tower (0112) Position Type: Regular Scheduled Hours: 40 Shift: First Shift Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process. Thank you for your interest in positions at The Ohio State University and Wexner Medical Center. Once you have applied, the most updated information on the status of your application can be found by visiting the Candidate Home section of this site. Please view your submitted applications by logging in and reviewing your status. For answers to additional questions please review the frequently asked questions. The university is an equal opportunity employer, including veterans and disability. At Ohio State, you’ll find work that inspires you. We offer roles and growth opportunities in countless fields and specialties — including a job that’s right for you. Ohio State benefits give you options to take care of what matters most to you — and opportunities to make adjustments as your life and needs change, including: • Medical, dental and vision coverage, with Ohio State paying a significant portion of the cost. • Paid time off, including sick and vacation time and 11 holidays. • State retirement plan or an alternative retirement plan, both with generous employer contributions. As Buckeyes, we accomplish more together. No matter your role, you’ll be part of creating what people need now: pathways to education, research and health care. Working at Ohio State means you’re part of a team with a strong sense of community and an unwavering commitment to excellence — and, of course, incomparable Buckeye spirit. We bring out the best in people, help each other succeed and learn together. By joining Ohio State, you become part of a top-20 public university with one of America’s leading academic health centers. 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