Job Description Role Overview The Sr. Director, Commercial Technology Business Engagement Leader – Kidney & Patient Services is responsible for executing and operationalizing commercial technology capabilities in direct support of the North America Kidney Business Unit and the Patient Services Program. Reporting the Executive Director, US Commercial Technology this role acts as the day‑to‑day technology leader embedded with Kidney commercial and patient services leadership, accountable for translating business priorities into deliverable roadmaps, funded initiatives, and reliable operations. The Sr. Director ensures that technology solutions—spanning CRM, digital engagement, data, analytics, and AI‑enabled workflows—are implemented effectively, adopted by the business, and operated reliably within a regulated environment. Key

Responsibilities

1. Kidney & Patient Services Technology Partnership Serve as the primary technology partner for Kidney Business Unit and Patient Services leaders and sitting member of their leadership teams, owning the translation of business priorities into executable technology and AI plans. Maintain deep understanding of Kidney go‑to‑market models, patient access and support workflows, and operational requirements. Support business planning cycles by shaping realistic delivery plans, sequencing, and dependency management for technology initiatives. 2. Roadmap Execution & Delivery Leadership Own the Kidney and Patient Services technology roadmaps, ensuring alignment to launch readiness, in‑market optimization, and evolving patient support needs. Lead delivery across programs, enhancements, and releases, ensuring quality, timeliness, and compliance. Manage intake, prioritization, and backlog execution in partnership with Product, Platform, and Data teams. 3. Operational Ownership & Governance Accountable for the run‑state performance of Kidney and Patient Services systems, including incident, change, release, and service management. Establish fit‑for‑purpose governance for demand management, release planning, and risk escalation within scope. Ensure solutions adhere to DTE system lifecycle, validation, and change management standards. 4. AI & Data Enablement (Execution Focus) Partner with Data, Analytics, and AI platform teams to implement and scale approved AI and analytics use cases relevant to Kidney and Patient Services. Drive business adoption through workflow integration, training, and change management. Ensure AI solutions are deployed in accordance with privacy, security, and promotional compliance guardrails. 5. Cross‑Functional & Vendor Coordination Coordinate execution across DTE teams including Core Technology, Data & Software Engineering, and Information Security. Manage day‑to‑day relationships with vendors and managed service partners supporting Kidney and Patient Services solutions. Track vendor performance, delivery outcomes, and operational SLAs within assigned scope. 6. Team & Financial Management Lead a delivery‑oriented team of onshore/offshore technical resources. Manage allocated operating and project budgets for Kidney and Patient Services initiatives. Develop team capability in Agile delivery, stakeholder management, and regulated commercial operations. Required Knowledge &

Experience

Strong experience supporting US commercial and/or patient services functions within biopharma or life sciences during launch phase. Hands‑on experience delivering and operating commercial platforms such as Salesforce CRM, Veeva, digital engagement, and patient services technologies. Working knowledge of data platforms and AI/analytics enablement, with a focus on implementation and adoption rather than strategy definition. Demonstrated ability to lead complex delivery portfolios in a matrixed, regulated environment.

Experience

managing offshore or managed service delivery models.

Education

&

Experience

Bachelor’s degree required (technology‑related discipline preferred). 12–15+ years of progressive technology experience, including senior delivery or domain leadership roles. 5+ years supporting US Commercial and/or Patient Services technology domains. US commercial launch or major indication expansion experience preferred.

Pay Range

$262,400 - $393,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.