What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Job Title - P04 – Staff PLM Operations

Job Summary

The Staff PLM Operations professional is responsible for leading and optimizing end-to-end Product Lifecycle Management (PLM) operational processes that support product development, product changes, master data management, and lifecycle governance. This role serves as a senior operational expert and trusted partner to Engineering, Quality, Regulatory, Supply Chain, Manufacturing, and IT teams to ensure efficient, compliant, and scalable PLM operations. The position drives operational excellence through process standardization, governance, automation, data quality improvements, and continuous improvement initiatives. Operating with a high degree of autonomy, the Staff PLM Operations professional collaborate with strategy, resolves complex business challenges, and delivers measurable improvements in quality, efficiency, and user experience. Key

Responsibilities

Serve as the enterprise SME for PLM Operations, providing leadership in lifecycle management, governance, and operational best practices. Lead and optimize critical PLM operational processes, ensuring reliable, scalable, and compliant execution across the product lifecycle. Establish and govern PLM standards, controls, and compliance frameworks, including audit readiness and regulatory adherence. Champion data governance and master data quality, driving resolution of complex data integrity issues and improving data lifecycle management. Drive operational excellence and continuous improvement initiatives to enhance efficiency, quality, scalability, and user experience. Define and manage operational KPIs, SLAs, dashboards, and forecasting, providing actionable insights for business and leadership decision-making. Lead digital transformation through automation, analytics, AI adoption, and PLM capability enhancements to improve operational effectiveness. Partners with Engineering, Quality, Regulatory, Manufacturing, Supply Chain, and IT teams to align business objectives, influence decisions, and lead strategic PLM initiatives. Mentor and coach junior team members to accelerate their technical capability, and operational effectiveness with project delegation to the junior team. Required

Qualifications

Bachelor’s degree in engineering, Business, Operations, or Life science graduation 8+ years of experience in PLM operations, program management, or business operations Strong experience working cross‑functionally to drive execution and deliver results Excellent written and verbal communication skills, including executive‑level communication Ability to work independently, manage ambiguity, and exercise sound judgment

Preferred Qualifications

Experience

in PLM systems and regulated environments (e.g., MedTech, Pharma) Familiarity with PLM governance models, KPIs, and operational metrics

Experience

supporting global teams and stakeholders Prefer experience with PLM Tools (e.g., Siemens Teamcenter, Agile PLM, SAP PLM), SAP S/4 PLM etc. Agentic AI and LLM applications in PLM ecosystem e.g., TeamCenter, SAP, LIMS, and Camstar We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship. The potential of genomics to change the world is unparalleled. At Illumina, we are leading the way. Our technology empowers researchers and clinicians globally to improve cancer treatments, change the course of diseases, protect the environment, and fight food insecurity. We are made up of dedicated professionals, all-in on creating a better world – and we need every skill set on our path to making genomics useful for all. Learn more about life at Illumina. Illumina has been made aware of fraudulent schemes in which individuals falsely claim to represent Illumina, our Talent Acquisition team, or our Human Resources organization. Please note: • All legitimate Illumina career opportunities are posted on the Illumina Careers website. • Illumina will never ask candidates to pay fees, transfer money, purchase equipment, or provide banking information during the recruitment process. • Illumina does not extend employment offers without a formal interview process. • Official recruiting communications will come from authorized Illumina email addresses (xxxxxx@illumina.com). If you are unsure whether a communication is legitimate, please contact us at [Talent Acquisition Contact Email] before sharing any personal information. Thank you for helping us protect the integrity of the hiring process and your experience.