Are you an expert in the skeletal muscle biology? Would you like to apply your research expertise to accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatments of Cardiovascular, Renal and Metabolic (CVRM) diseases! We are seeking a passionate and accomplished Associate Principal Scientist with expertise in skeletal muscle physiology, metabolism and drug discovery to join our vibrant research community Metabolism Bioscience division within Research and Early Development CVRM. The position is primarily based at AstraZeneca’s Global R&D site in Gothenburg, Sweden. For exceptional candidates, placement at our Gaithersburg, US site will be considered. CVRM is one of the three main therapeutic research areas within BioPharmaceuticals AstraZeneca which deliver candidate drugs into clinical development. The CVRM Bioscience department has a dynamic environment that fosters collaboration and innovation. We are a team of professionals who are passionate about advancing science to discover and develop novel therapeutics that will benefit patients suffering from obesity, diabetes and their co-morbidities. Accountabilities This scientific leadership role offers an exciting opportunity to set strategic direction and shape the future of obesity and weight management, with a focus on mechanisms underlying healthy body weight loss and maintenance. You will: Apply your expertise in skeletal muscle physiology and metabolic diseases to drive scientific and technical innovation, advancing new therapeutic interventions. Lead multidisciplinary project teams across Gothenburg (Sweden), Cambridge (UK), and Gaithersburg (US), as well as external collaborators, to deliver key experimental data and progress the drug project portfolio. Champion novel approaches to drug discovery in healthy weight loss and body weight maintenance, facilitating scientific debate and innovation through leadership and mentorship within the CVRM Research community. Contribute to the evolution of research strategy within the Metabolism Bioscience division. Play a lead role in the selection and validation of research targets, taking projects from discovery through to early clinical development, and serve as bioscience lead on discovery projects. Raise the scientific profile of CVRM both internally and externally through high-impact publications, conference presentations, and collaborative initiatives. Report directly to the Head of Metabolism Bioscience Division. Essential Skills/
Experience
PhD and postdoctoral experience in life sciences or equivalent relevant industry experience. 3-5 years’ drug discovery experience in academia, biotech, or pharmaceutical industry following postdoctoral research. Deep expertise in skeletal muscle biology and physiology, including in vitro and in vivo assay development. Strong scientific knowledge of metabolic diseases and mechanisms of body weight regulation, alongside a strong track record of leading laboratory-based research.
Experience
in new model development, laboratory techniques, and enthusiasm for performing hands-on science. Demonstrated scientific leadership reflected by a robust publication record, external presentations, and collaborations. Proven ability to manage multifaceted projects and establish research collaborations, leveraging a broad professional network. Desirable Skills/
Experience
Significant experience with in vitro, in vivo, and ex vivo technologies to assess multiple target classes. Track record as a Project leader or Bioscience lead, conducting, planning, and guiding complex scientific projects within multidisciplinary teams. Demonstrable ability to manage multiple concurrent projects or tasks. Extensive network and collaboration experience within the metabolism research field. AstraZeneca is committed to making a difference by fusing data and technology with scientific innovations to achieve breakthroughs. We empower our teams to explore the biology of complex diseases, making bold decisions without fear of failure. Our inclusive environment fosters collaboration across academia, biotechs, and industry, leveraging diverse global knowledge for swift impact on disease. With opportunities for continuous learning and career development, AstraZeneca is where curious minds thrive as we push the boundaries of science to deliver life-changing medicines. Ready to make an impact? Apply now to join our team! Welcome with your application no later than 25 August 2026. Date Posted 11-aug.-2026 Closing Date 10-aug.-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.