Are you a scientist with a passion for clinical drug development and a strong scientific foundation, who wants to learn the craft of clinical science on breakthrough cell and immunotherapies for immune-mediated neurological disease? Do you have sharp analytical instincts, a search-and-find mindset in complex clinical data, and the collaborative temperament to thrive in a cross-functional team? If so, we invite you to join us. We are seeking a Clinical Scientist, Neuroimmunology to support our neuroimmunology portfolio, starting in multiple sclerosis and extending to additional immune-mediated indications and modalities. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that discovers, develops and commercializes prescription medicines for some of the world's most serious diseases. Within Immunology R&D, our Neuroimmunology team is building a world-class capability to accelerate the delivery of transformative cell therapies and immunotherapies for patients with immune-mediated neurological disease. AZ is a place built on courage, curiosity and collaboration, and we make bold decisions driven by patient outcomes. The Associate Director, Clinical Scientist is a member of a multi-disciplinary study team, working in close partnership with the Study Physician and fellow clinical scientists. You will provide clinical-scientific support to help monitor, track, and analyze participant data across the study lifecycle, and contribute to the documents and day-to-day clinical-science work that keep studies inspection-ready and decision-enabling. You will collaborate with all groups involved in clinical development, including Clinical Operations, Data Management, Biostatistics, Clinical Pharmacology (DMPK), Pharmacovigilance, Translational Medicine, and Regulatory. This is an excellent opportunity to build clinical-development craft on advanced modalities within a supportive, mentoring team. You will report to the Global Clinical Head, Neuroimmunology, or their designee, and work closely with the Study Physician, fellow clinical scientists, and the Global Clinical Program Lead (GCPL), who leads the program's clinical development strategy. Medical-judgement questions are escalated to the Study Physician, and program-strategy items to the GCPL. Typical Accountabilities - Clinical data review and monitoring Support ongoing review, tracking, and analysis of clinical-trial participant data, reviewing patient profiles, data listings, summary tables, laboratory and other safety parameters, and coded terms for consistency and completeness. Contribute to the interpretation of emerging clinical data and identification of clinically meaningful findings, trends, and questions for further evaluation by the study team. Assist with routine safety and efficacy data review, help flag events of interest or data trends needing further investigation, and prepare preliminary summaries for the study team. Contribute to query generation, coding reconciliation (AE/SAE, medical/surgical history, concomitant medications), and edit-check refinement in collaboration with Data Management and Biostatistics, and support database-lock readiness activities and cross-checks. Documents and operational translation Contribute to authoring and review of clinical documents in alignment with the clinical development plan, such as protocols and amendments, protocol clarification letters, IBs, ICFs, CRFs and eCRF completion guidelines, medical monitoring plans, charters, lab and pharmacy manuals, and training materials. Help translate protocol intent into operational deliverables, and support maintenance of the protocol clarification log. Contribute to preparation and review of safety narratives, regulatory-submission sections, responses to health-authority requests, and materials for safety review committees (SRC, IDMC, DMC), including data review and presentation preparation. Endpoint integrity (MS-specific) Support the operational integrity of MS assessments, such as central MRI charter adherence, EDSS scoring quality and rater reliability, and relapse-adjudication package completeness, in collaboration with the study team and Study Physician. Analysis, literature, and communication Perform analyses and generate scientific slide decks based on clinical, translational, and other datasets, and help communicate clear overviews of trial data. Review and synthesize scientific literature and competitive intelligence to support study and program strategy, and contribute to abstracts, posters, manuscripts, and conference materials. Support the review of statistical analysis plans and table, listing, and figure shells for traceability from protocol to outputs. Collaboration and deviations Serve as a supporting point of contact for routine scientific and procedural questions from sites and CROs, draft clarifications for team review, and support site initiation visits and investigator meetings. Assist with deviation trending and CAPAs in partnership with Clinical Operations and vendors, documenting rationale and escalating clinical-impact items appropriately. Maintain up-to-date knowledge of relevant science, GCP, and regulatory guidance. Essential
Qualifications
and Skills Master's degree in a life-sciences or related field with minimum 2 years relevant clinical or scientific research experience, or an advanced degree (for example PhD, PharmD, MD, MPH, MSN/RN, or equivalent) in a life-sciences or related field. Industry clinical-development experience is a plus but not required at this level. Understanding of clinical-trial design, statistical concepts, and the connection between nonclinical and clinical data. Familiarity with ICH, GCP, and relevant regulatory requirements. Strong analytical skills and a genuine curiosity for patterns in complex clinical data, with meticulous attention to detail. Ability to work collaboratively in a fast-paced matrix environment, and the ability to follow complex direction reliably Sound judgment in handling confidential, regulated information, high ethical standards, initiative, and a collaborative, trustworthy team orientation. Desirable Skills
Experience
in, or strong interest in, cellular therapies, CAR-T, and/or T-cell-engager trials.
Experience
in neurology, multiple sclerosis, or other immune-mediated disease.
Experience
with Phase 1 and Phase 2 clinical trials. Data-analysis and programming familiarity (for example R, SAS, Python) and clinical-review tools (for example Medidata Rave, J-Review). Ability to travel nationally and internationally as needed. The annual base pay for this position ranges from $142K to $213K. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
Benefits
offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 05-Aug-2026 Closing Date 16-Aug-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.