Major responsibilities • Develop and drive robust upstream process workflows to support efficient plasmid DNA and viral vectors manufacturing. This involves designing and executing experiments, analyzing data, and providing science-based recommendations for process improvement. • Apply in-depth expertise in E. coli fermentation, mammalian cell culture, multivariate Design of Experiments (DoE), and in-process analytics to design, scale up, improve productivity, optimize parameters for product quality, characterize upstream production processes, and minimize process- and product-related impurities. • Drive platform development and evaluate new technologies and innovations (i.e. industry trends, emerging technologies, and best practices in plasmid DNA development) to improve process performance and operational efficiency, enable predictive process modeling, and strengthen process control and robustness. • Support technical investigations via equipment troubleshooting and testing to identify root causes. • Analyze, document, and present experimental data and findings to internal teams and relevant stakeholders as needed. • Work closely with cross-functional stakeholders to ensure programs are on track and to facilitate the seamless transfer of developed processes to manufacturing teams, providing detailed documentation, training, and ongoing technical support. • Ensure accurate, complete, and compliant documentation and record keeping, including databases, batch records, ELNs, and other required technical records. • Author and review technical documents such as laboratory and equipment SOPs, batch records, process development reports, and process transfer documents. Compile and/or support the preparation of documentation for regulatory submissions, as required. Education, Qualifications, Skills and Experience • M.S. or above in Biology, Biotechnology, Microbiology, Biochemical Engineering, or equivalent related fields. Candidates with more extensive relevant experience will be considered for a senior scientist position. • Minimum of 3 years of hands-on experience in upstream process development within biopharmaceutical or biotechnology settings, including manufacturing, pilot-scale, and/or laboratory-scale environments. The candidate should have direct experience in upstream process operations, including development of scalable suspension processes for plasmid DNA and/or viral vector product manufacturing. • Experience in plasmid DNA production and scale-up bioreactor operation is a must. • Strong knowledge and hands-on experience in upstream Batch / Fed-Batch process development, upstream process optimization, operation of bioreactors, and process scale-up / scale-down model development. • Demonstrated ability to coach and mentor junior scientists. • Creative thinker that can identify and efficiently improve processes to address issues and gaps. • Independently motivated and good problem-solving ability. • Proficiency with statistical analysis software (e.g., JMP/MODDE/Minitab) is highly desired. • Attention to detail and accuracy in developing, reviewing, and following protocols, SOPs, batch records and technology transfer documents is a must. • Demonstrated ability to collaborate effectively across cross-functional teams to meet project deliverables and timelines. • Strong verbal and written communication, decision-making and organizational skills. Date Posted 14-Aug-2026 Closing Date 30-Dec-2026 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.