Job Description Position Summary Vertex is entering an exciting phase of commercial diversification. As we expand into new pipeline disease areas and new geographies, we are investing in data, technology, and AI to scale commercial operations globally. The Commercial, Medical and External Affairs Technology team is expanding our capabilities with increased investment in data, platforms, and AI. This role establishes the end-to-end architecture required to scale AI and digital capabilities across the enterprise. The Senior Director, Commercialization Technology Architect is responsible for defining and governing target-state architectures, integration patterns, and platform standards that enable scalable, secure, and compliant AI solutions. This role ensures technologies deployed by Product, Data, and Engineering teams are aligned to enterprise architecture, interoperable across systems, and built for long-term scale. This is a technical architecture leadership role focused on translating business and product direction into production-ready system design, data flows, and platform integration. Key
Responsibilities
Architecture Strategy & Standards Define and maintain target-state architecture across Commercial and Medical ecosystems Establish reference architectures, design patterns, and engineering standards for AI-enabled systems Govern architecture alignment across CRM, omnichannel, patient services, and enterprise platforms Ensure consistency with enterprise architecture and platform strategies Integration & Data Architecture Own integration patterns and data flows across Salesforce, Veeva, data platforms, and downstream systems Define real-time and batch data architectures, including event-driven patterns and APIs Ensure alignment with enterprise data platforms (e.g., MDM, Snowflake, Databricks) Partner with Data teams to ensure data readiness, lineage, and interoperability Technology & Platform Governance Partners with engineering function and core technology to define standards across cloud and data platforms MDM, Snowflake, Databricks, Snowflake supporting Commercial and Medical affairs domains Lead architecture decisions for build vs. buy vs. partner solutions Establish environment, deployment, and DevOps architecture patterns within the Commercial and Medical affairs domains Maintain architecture documentation for scalability, reuse, and audibility Security, Risk & Compliance Ensure architectures meet SOX, GxP, privacy, and security requirements Define patterns for observability, audibility, and controls in AI systems Partner with InfoSec, Legal, Privacy, and Quality to embed compliance by design Delivery Enablement Partner with Product Management, Engineering, and Data teams to translate product requirements into executable architectures Provide hands-on guidance to ensure solutions are production-ready and aligned to standards Serve as final architecture authority for design reviews and major platform decisions Knowledge & Skills Deep expertise in enterprise architecture, solution design, and distributed systems Strong experience with CRM and commercial platforms (Salesforce, Veeva) Proven ability to design complex integrations and data architectures at scale Hands-on experience with cloud and data warehouse platforms (AWS, Azure, Snowflake, etc...) and modern data stacks
Experience
designing systems incorporating AI/ML and LLM-based capabilities Strong understanding of AI architectures (e.g. MCP) Expertise in security, compliance, and regulated environments (SOX, GxP) Ability to translate complex architecture into clear guidance for engineering teams
Education
&
Experience
Bachelor’s or Master’s degree in Computer Science, Engineering, or related field 12+ years of experience in enterprise architecture or solution architecture roles
Experience
in pharma, biotech, or regulated healthcare environments strongly preferred Proven track record delivering enterprise-scale platform and integration architecture
Experience
working across Commercial, Medical, or patient services systems
Pay Range
$228,000 - $342,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.