Job Description Vertex is seeking a Senior Principal AI Engineer to design, build, and optimize the shared platform capabilities that power AI-enabled products and intelligent workflows across the enterprise. Working within the Agentic AI Platform team, this role will focus on delivering production-grade platform services for model integration, prompt and workflow orchestration, evaluation, observability, performance optimization, and agent lifecycle management. A key focus of this role will be enabling a build/bring-your-own-agents capability within the Agentic AI Platform, allowing teams across Vertex to create, integrate, customize, and operationalize their own agents using shared platform standards, tooling, and governance controls. The ideal candidate combines strong software engineering fundamentals with deep experience in applied AI systems. This individual will be comfortable operating across rapid experimentation and engineering rigor, translating emerging AI capabilities into scalable, reliable, secure, and reusable platform components. The Senior Principal AI Engineer will play a critical leadership role in accelerating AI adoption across Vertex by enabling product teams to build and deploy AI solutions faster and more effectively. Key
Responsibilities
Build/bring-your-own-agents capability (primary focus): the frameworks, SDKs, templates, interfaces, and guardrails that let teams across Vertex create, integrate, customize, and operationalize their own agents on shared platform standards Platform services: model integration, prompt and workflow orchestration, tool use, memory patterns, and agentic task coordination that other teams build against Agent lifecycle and quality: registration, configuration, testing, deployment, versioning, monitoring, and retirement, plus the evaluation and benchmarking frameworks behind them Developer experience: self-service onboarding, documentation, reference implementations, and enablement resources that shorten the path from idea to production Standards and technical leadership: platform APIs, service contracts, architecture patterns, and the engineering practices that keep custom agents safe, reliable, and supportable Architect and develop shared AI/agentic platform services that support enterprise AI products and internal workflows Design and implement a build/bring-your-own-agents capability that enables teams to create, register, integrate, deploy, and manage their own agents within the enterprise agentic platform Establish reusable frameworks, SDKs, templates, interfaces, and guardrails that standardize how custom agents are built and onboarded onto the platform Own the developer experience for the platform, delivering intuitive self-service onboarding, SDKs, CLIs, sandbox environments, reference implementations, and clear documentation that let builders move from idea to production quickly Define agent lifecycle capabilities including agent registration, configuration, testing, deployment, monitoring, versioning, and retirement Build and maintain robust integrations with foundation models, model gateways, APIs, enterprise tools, and related AI infrastructure Design and implement systems for prompt orchestration, workflow execution, tool use, memory patterns, and agentic task coordination Develop reusable frameworks and services for evaluation, benchmarking, and validation of AI model, agent, and workflow performance Establish platform capabilities for observability, monitoring, tracing, logging, and alerting across AI workloads and autonomous agent interactions Optimize platform performance, scalability, latency, reliability, and cost efficiency for production AI and agentic systems Partner with product, data, engineering, security, and architecture teams to enable enterprise-ready AI solutions Translate prototypes and experimental concepts into hardened, maintainable, production-grade services Define engineering standards, best practices, and design patterns for AI platform development and deployment Support governance, risk management, and responsible AI practices through measurable controls, policy enforcement, and technical safeguards for agent behavior Drive platform adoption by creating reusable components, documentation, onboarding patterns, and developer enablement resources Mentor engineers and provide technical leadership across AI platform initiatives Evaluate emerging tools, frameworks, and architectural patterns in generative AI and agentic systems to inform platform strategy Required
Qualifications
Bachelor’s degree in Computer Science, Software Engineering, Machine Learning, Data Engineering, or a related technical field; advanced degree preferred Significant industry experience in software engineering, machine learning engineering, or AI platform development, including experience in senior or principal-level technical roles Proven track record designing and delivering production-scale AI or ML platforms Strong experience building distributed systems, APIs, microservices, and cloud-native applications Demonstrated experience operationalizing machine learning, generative AI, or agent-based solutions in enterprise environments
Experience
designing extensible platform capabilities that enable internal teams to build or integrate custom applications, tools, or services Deep understanding of software engineering best practices including testing, CI/CD, version control, code review, and system reliability Deep understanding of AI-native software engineering practices and experience establishing standards, governance, and best practices for the responsible use of AI coding assistants and software engineering agents across engineering teams
Experience
defining architecture, standards, and reusable services for large-scale enterprise environments
Experience
leading complex technical initiatives and influencing architecture across cross-functional teams Strong communication skills with the ability to explain complex technical concepts to varied audiences
Experience
balancing experimentation speed with production engineering discipline, security, and maintainability Technical Skills Required AI/ML platform architecture Generative AI systems and large language model integration Agentic workflows and orchestration frameworks Multi-agent or autonomous agent system design Prompt engineering and prompt management Workflow orchestration and automation Agent lifecycle management Model evaluation, benchmarking, and performance measurement AI observability, tracing, monitoring, and logging API design and service integration Distributed systems and scalable backend engineering Cloud platforms and cloud-native deployment patterns Productionization of AI/ML services Reliability, latency, throughput, and cost optimization CI/CD pipelines and DevOps/MLOps practices Secure software development and enterprise platform controls Preferred Skills Advanced degree in Computer Science, Artificial Intelligence, Machine Learning, or a related discipline
Experience
with enterprise AI platforms, developer platforms, or internal tooling ecosystems
Experience
building frameworks or platforms that support bring-your-own-component or extensible developer patterns Demonstrated focus on developer experience, including designing self-service onboarding, SDKs, CLIs, sandboxes, templates, and documentation that reduce friction and accelerate time-to-first-deployment for internal builders Familiarity with model gateways, retrieval-augmented generation, and evaluation frameworks
Experience
implementing AI governance, responsible AI controls, and compliance-oriented technical solutions Knowledge of vector databases, knowledge retrieval systems, and orchestration layers for intelligent applications
Experience
in regulated industries such as biotechnology, pharmaceuticals, healthcare, or life sciences Strong mentoring and technical leadership experience in highly collaborative environments Ability to assess emerging AI technologies and translate them into practical platform capabilities #LI-HYBRID
Pay Range
$188,000 - $282,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.