About the team Predictive AI and Data team is responsible for providing AI and Bioinformatics solutions to the scientists across the spectrum of drug development and discovery in AstraZeneca (both pre-clinical and clinical stages). The primary aim is to find ways to accelerate the drug development process by leveraging existing company data in combination with the most cutting-edge AI approaches in day-to-day scientific work across the company. Introduction to role In this role you will lead the next‑generation predictive safety modelling at scale, applying chemoinformatics, bioinformatics and AI/ML to deliver decision-shaping safety insights and cross-functional scientific leadership. Provide scientific leadership for predictive safety modelling, integrating chemical and biological data (e.g., Safety Omics, Cell Painting, NAMs) to inform risk assessment and progression decisions. This is a fully hands-on, computational role with cross-functional influence. Accountabilities Develop, optimise and deploy predictive safety models using chemoinformatics, bioinformatics and ML/DL. Create reproducible workflows, data QC procedures and model validation frameworks. Integrate multimodal data: chemical descriptors, omics, imaging and NAM datasets. Serve as scientific lead for project teams and influence program strategy. Drive innovation and identify strategic modelling opportunities across R&D. Lead collaborations with academia, consortia and technology partners. Mentor junior scientists and contribute to capability building. Communicate complex modelling concepts to diverse scientific and governance audiences. Essential Skills/

Experience

PhD in Chemoinformatics, Bioinformatics, Computational Toxicology or related field. Strong AI/ML experience (PyTorch, TensorFlow, scikit-learn). Advanced Python or R programming skills. Familiarity with GitHub, CI/CD pipeline, and best DevOps and MLOps practices

Experience

with multimodal biological + chemical datasets. Proven leadership in delivering impactful modelling work. Excellent communication and stakeholder engagement skills. Acts as discipline leader and shapes scientific strategy. Solves complex problems using scientific judgement. Builds strong cross-functional relationships and networks. Coaches and mentors others, enhancing team capability. Desirable Skills/

Experience

Experience

with Safety Omics, Cell Painting or imaging data. Background in toxicology, pharmacology or ADME.

Experience

with cloud computing or workflow automation. Track record of publications in top AI conferences or journals in pharmaceutical research (e.g., NeurIPS, ICML, Nature Machine Intelligence, Nature Communications, NEJM AI, etc.)

Experience

supervising scientists or managing collaborations. Date Posted 17-8月-2026 Closing Date AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.