Job Title: Medical Lead, Chronic Lymphocytic Leukemia (CLL) Location: Gaithersburg, MD (US) - This is a hybrid role, onsite requirement Welcome to the Oncology Business Unit at AstraZeneca! This is the place to build a world-class career in a dedicated Oncology unit. Here, we are always looking to learn more, welcoming the varied opportunities to expand our horizons or develop niche expertise. Embrace the unparalleled access to industry-leading research, technology, and pipeline product launches with a footprint in every region. Coupled with our agility and sharp focus on talent development, there is an exciting opportunity to accelerate a rewarding and meaningful career. Accountabilities: As Medical Lead, Chronic Lymphocytic Leukemia (CLL), you will help shape and deliver the US Medical Affairs strategy for a priority hematology oncology indication. In this highly visible role, you will lead the Core Medical Team, develop and execute the integrated medical plan, and use scientific, clinical, customer, and multi-channel insights to inform evidence generation, product development, and launch readiness. You will collaborate across Medical, Clinical Development, Patient Safety, Commercial, Market Access, and Field Medical teams to advance science-driven strategies with meaningful impact for patients and the CLL community. Key responsibilities include managing a portfolio of investigator-initiated studies that complement the AstraZeneca clinical development plan, leading the real-world evidence strategy for the assigned indication or asset from concept through execution and communication, and creating the US publication plan for generated evidence. You will also provide medical review and input for key materials, engage strategic external partners, contribute to safety discussions, and support scientific exchange with field medical and key account teams. Essential Skills/

Experience

A Doctorate in Medicine (M.D, D.O), PhD or PharmD degree plus proven experience A minimum of 5+ years of related work experience in industry, clinical or research institution, preferably in onco-hematology, solid tumors, or related experiences 1-3 years in HQ Medical Affairs role Expert technical depth in disease area – Hematology/Oncology Thorough understanding of drug development and pharmaceutical market support and in-depth knowledge of Hematology/Oncology (clinical evidence and real-world patient management) Strong leadership with a proven track record of change and impact Strong business acumen skills and experience with financial management Proven ability to interact productively with both commercial and scientific/medical colleagues (including Clinical Development teams), with ability to engage and influence senior stakeholders and work collaboratively in cross-functional teams Ability to travel nationally and internationally. Travel will be, as appropriate, up to ~30% of the time Excellent written and oral communication, interpersonal, negotiation and presentation skills Desirable Skills/

Experience

Active license as Doctorate in Medicine (M.D, D.O), PhD or PharmD degree Additional training such as an M.P.H., M.B.A., or other advanced degree Product Launch

Experience

and FDA requirements

Experience

working in US market,

Experience

in supporting brands or disease area levels in-country, regional, or global organizations is preferred

Experience

with the clinical management of leukemia disease, chronic and/or acute

Experience

in evidence generation planning and clinical trial design

Experience

in a strategy-setting role within Medical Affairs and navigating sophisticated business challenges

Experience

in developing and maintaining a network that includes third-party expert Background in practicing medicine, clinical research, and familiarity with biostatistics, epidemiology and health outcomes Knowledge of relevant Professional Societies and Scientific Medical Experts. Line management (People leadership) with demonstrated coaching and mentoring experience In Medical Affairs at AstraZeneca, we change the practice of medicine and improve the patient experience by generating and communicating compelling medical evidence. We translate the wealth of medical and scientific expertise to ensure the data we produce helps physicians to better treat patients at every point in the journey. We are proud to work on the cutting-edge with one of the broadest and deepest Oncology pipelines in the business. Help to advance our pipeline by applying scientific expertise and accelerating our pathway to finding a cure. Ready to make a difference? Apply today and join us in our mission to redefine cancer treatment and eliminate cancer as a cause of death The annual base pay (or hourly rate of compensation) for this position ranges $193,281.60 - $289,922.40 USD . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.

Benefits

offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 07-Aug-2026 Closing Date 31-Aug-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.