Are you ready to dive into the world of transformative therapies and make a significant impact? At EsoBiotec, now part of AstraZeneca, we are setting new benchmarks for biotechnological research. Our collaboration combines AstraZeneca’s global influence and scientific innovation with EsoBiotec’ s unique culture of creativity and breakthroughs in cell-based therapies and immunology. Here, your scientific passion will drive real-world impact as you contribute to life-changing treatments. We are looking for an inspiring Senior Scientist Vector Engineering to drive innovation and development of our pioneering lentiviral vector therapeutic platform. Join us in shaping the future of cell and gene therapy with your expertise in viral vector engineering, gene editing, CAR and TCR T cell engineering or myeloid immunobiology in cancer. You will report to the Associate Director In Vivo Cell Therapy and be based in Cambridge, MA.

Responsibilities

Design, build, and validate novel lentiviral vectors for in vivo cell therapy applications. Perform hands-on construct designs, viral genome optimization, viral envelope pseudotype engineering and vector assembly. Design, plan and execute in vitro and in vivo experiments to assess transduction efficiency, specificity, expression durability, and safety profile of novel in vivo LVVs. Develop and run assays for titer, potency, biodistribution, integration site analysis, and immunogenicity in collaboration with analytics partners. Apply literature mining, public datasets, and personal expertise to generate innovative, testable hypotheses and prioritize vector concepts. Implement rigorous experimental design, statistical analysis, and documentation to ensure reproducibility, traceability, and data integrity. Collaborate extensively with discovery teams across AZ including payload biology, bioinformatics, and nonclinical to align vector designs with product requirements. Contribute to platform development by creating screening workflows, model systems, and standardized protocols for vector performance. Present findings, risks, and recommendations in working groups and project meetings and drive decisions through clear data storytelling. Support IP generation by contributing to invention disclosures and sharing FTO considerations with the IP team. Essential Skills/

Experience

PhD in molecular biology, virology, bioengineering, or related field with 2+ years of postdoctoral experience in academia or industry. Demonstrated expertise in viral vectors and virology with a strong track record in viral vector design, engineering, and characterization for gene therapy Proficiency in molecular biology techniques for vector construction, promoter and regulatory element engineering, and payload optimization.

Experience

in protein and antibody (scFV and VHH) engineering or envelope/pseudotype modification to tune tropism, entry, and transduction profiles. Hands-on familiarity with in vitro cell culture assays and in vivo models for vector evaluation including transduction assays, dose–response, durability studies, and safety readouts. Strong hands-on competence with quantitative analytics such as flow cytometry and qPCR/ddPCR. Ability to design rigorous experiments, apply statistics, and interpret complex datasets to drive go/no-go decisions. Strong collaboration and communication skills to operate as a backbone member of cross-functional working groups and align discovery efforts with product goals. Evidence of innovation through publications, presentations, or open-source contributions and comfort leveraging literature and public data to ideate and de-risk. Organized, proactive, and product-focused mindset with the ability to manage multiple experiments, meet timelines, and maintain high-quality documentation. Commitment to being fully hands-on at the bench while mentoring peers and contributing to platform and program deliverables. Desirable Skills/

Experience

Strong preference for lentiviral vectors. Practical understanding of safety risks and mitigations for LVV including insertional mutagenesis, off-target transduction, immunogenicity, and RCL testing. When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world. The annual base pay for this position ranges from $118K to $178K. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.

Benefits

offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 17-Aug-2026 Closing Date 23-Aug-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.